https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53604 75% (AUC = 0.79, SE = 0.014). Discrimination between ISO lesions and cNAWM was accomplished with an accuracy of >69% (AUC = 0.74, SE = 0.018), while discrimination between BH lesions and cNAWM was achieved at an accuracy of >80% (AUC = 0.87, SE = 0.021). Conclusions: Our results highlight the potential of APTw imaging for use as a non-invasive technique that is able to provide essential molecular information to clinicians and researchers so that the stages of inflammation and degeneration in MS lesions can be better characterized.]]> Wed 07 Feb 2024 14:34:19 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54037 Tue 30 Jan 2024 13:42:08 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54334 Tue 20 Feb 2024 16:06:06 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53980 pFDR ≤ 0.001; false-detection-rate (FDR)-corrected). There was a significant decrease in WML diffusivities and an increase in FA over the follow-up period in most TOIs (pFDR ≤ 0.001). Additionally, there were no differences in DTI parameters across treatment groups. AD and MD were positively correlated with fatigue scores (r ≤ 0.33, p ≤ 0.01) in NAWM-TOIs, while disability (EDSS) was negatively correlated with FA in most NAWM-TOIs (|r|≤0.31, p ≤ 0.01) at both time points. Disability scores correlated with all diffusivity parameters (r ≤ 0.29, p ≤ 0.01) in most WML-TOIs at both time points. Conclusion: Statistically significant changes in diffusion metrics in WML might be indicative of integrity improvement over two years in CTS tracts in clinically stable pw-RRMS. This finding represents structural changes within lesioned tracts. Measuring diffusivity in pw-RRMS affected tracts might be a relevant measure for future remyelination clinical trials.]]> Thu 25 Jan 2024 12:56:51 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51918 Fri 22 Sep 2023 10:40:32 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55343 Fri 17 May 2024 15:51:26 AEST ]]>